歡迎來到裝配圖網(wǎng)! | 幫助中心 裝配圖網(wǎng)zhuangpeitu.com!
裝配圖網(wǎng)
ImageVerifierCode 換一換
首頁 裝配圖網(wǎng) > 資源分類 > PDF文檔下載  

【病毒外文文獻(xiàn)】2010 Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease

  • 資源ID:7038634       資源大小:52.96KB        全文頁數(shù):2頁
  • 資源格式: PDF        下載積分:10積分
快捷下載 游客一鍵下載
會(huì)員登錄下載
微信登錄下載
三方登錄下載: 微信開放平臺(tái)登錄 支付寶登錄   QQ登錄   微博登錄  
二維碼
微信掃一掃登錄
下載資源需要10積分
郵箱/手機(jī):
溫馨提示:
用戶名和密碼都是您填寫的郵箱或者手機(jī)號(hào),方便查詢和重復(fù)下載(系統(tǒng)自動(dòng)生成)
支付方式: 支付寶    微信支付   
驗(yàn)證碼:   換一換

 
賬號(hào):
密碼:
驗(yàn)證碼:   換一換
  忘記密碼?
    
友情提示
2、PDF文件下載后,可能會(huì)被瀏覽器默認(rèn)打開,此種情況可以點(diǎn)擊瀏覽器菜單,保存網(wǎng)頁到桌面,就可以正常下載了。
3、本站不支持迅雷下載,請(qǐng)使用電腦自帶的IE瀏覽器,或者360瀏覽器、谷歌瀏覽器下載即可。
4、本站資源下載后的文檔和圖紙-無水印,預(yù)覽文檔經(jīng)過壓縮,下載后原文更清晰。
5、試題試卷類文檔,如果標(biāo)題沒有明確說明有答案則都視為沒有答案,請(qǐng)知曉。

【病毒外文文獻(xiàn)】2010 Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease

204 Pulmonary Disease Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease Gorse GJ O Connor TZ Hall SL et al Dept of Veterans Affairs Med Ctr and Saint Louis Univ Missouri Dept of Veterans Affairs Cooperative Studies Program Coordinating Ctr West Haven Connecticut et al J Infect Dis 199 847 857 2009 Background The clinical features and incidence of human corona virus HCoV infections in chronically ill older adults need better definition Methods HCoV infection was determined on the basis of a 4 fold increase in serum antibody and the detection of HCoV by reverse transcription polymerase chain reaction Laboratory documented influ enza LDI was detected by serologic assay and culture HCoV illnesses were compared with other acute respiratory illnesses identified by active surveillance during the 1998 99 winter respiratory virus season of 2215 patients with chronic obstructive pulmonary disease who were 50 years old and who received influenza vaccines Results HCoV 229E and HCoV OC43 were associated with 90 14 of 665 illnesses HCoV 229E in 22 HCoV OC43 in 67 and both in 1 LDI with 107 16 of 678 illnesses In multivariate logistic regression analysis myalgia was less likely with HCoV infection than with LDI OR 0 27 95 confidence limit 0 13 0 58 A majority of these HCoV and LDI illnesses exhibited each of 11 symptoms and signs of acute respiratory illness Spirometric results worsened most often with LDI and many acute respiratory illnesses regardless of etiology were associated with hospitalization A total of 8 illnesses were associated with HCoV NL63 1 with HCoV HKU1 Conclusions The frequencies of HCoVand LDI illnesses were similar HCoV illness was less severe than LDI illness was accompanied by multiple respiratory and systemic symptoms and was associated with hospitalization In late 2002 and early 2003 a deadly sudden respiratory illness was reported initially from Asia and then from multiple other countries This frightening illness termed sudden acute respiratory syndrome SARS was soon found to be caused by a coronavirus and respect for this virus often considered a common cold virus rose to a whole new level In fact there are many strains of coronavirus and the outbreak of SARS prompted significant increased research into this RNA virus and its potential role in human respiratory prob lems The authors studied acute respiratory illness exacerbations in more than 2200 chronic obstructive pulmonary disease COPD patients in one winter flu season In this population that had received influenza vaccination almost a third of the respiratory illnesses that winter were caused by either coro navirus or influenza virus as measured by serologic evidence of infections culture or polymerase chain reaction Coronaviral infections were associated with most of the same symptoms as influenza infections and resulted in Chapter 5 Community Acquired Pneumonia 205 clinically severe enough infections to warrant hospitalization In both groups about one fourth of the infected patients required hospitalization Clearly coro navirus strains present a spectrum of human respiratory ranging all the way from colds to often lethal SARS It also causes a substantial number of exacerbations in COPD patients and needs to be kept in mind when assessing and managing these patients J R Maurer MD MBA Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells Sajjan U Wang Q Zhao Y et al Univ of Michigan Ann Arbor et al Am J Respir Crit Care Med 178 1271 1281 2008 Rationale Secondary bacterial infection following rhinovirus RV infection has been recognized in chronic obstructive pulmonary disease Objectives We sought to understand mechanisms by which RV infec tion facilitates secondary bacterial infection Methods Primary human airway epithelial cells grown at air liquid interface and human bronchial epithelial 16HBE14o cells grown as polarized monolayers were infected apically with RV Transmigration of bacteria nontypeable Haemophilus influenzae and others was assessed by colony counting and transmission electron microscopy Transepithelial resistance R T was measured by using a voltmeter The distribution of zona occludins ZO 1 was determined by immunohistochemistry and immunoblotting Measurements and Main Results Epithelial cells infected with RV showed 2 log more bound bacteria than sham infected cultures and bacteria were recovered from the basolateral media of RV but not sham infected cells Infection of polarized airway epithelial cell cultures with RV for 24 hours caused a significant decrease in R T without causing cell death or apoptosis Ultraviolet treated RV did not decrease R T sug gesting a requirement for viral replication Reduced R T was associated with increased paracellular permeability as determined by flux of fluores cein isothiocyanate FITC inulin Neutralizing antibodies to tumor necrosis factor TNF a IFN g and IL 1b reversed corresponding cyto kine induced reductions in R T but not that induced by RV indicating that the RV effect is independent of these proinflammatory cytokines Confocal microscopy and immunoblotting revealed the loss of ZO 1 from tight junction complexes in RV infected cells Intranasal inoculation of mice with RV1B also caused the loss of ZO 1 from the bronchial epithe lium tight junctions in vivo Conclusions RV facilitates binding translocation and persistence of bacteria by disrupting airway epithelial barrier function Rhinovirus which is probably the most common virus causing the common cold does not typically cause lower respiratory tract infection and does not significantly destroy the respiratory epithelium 1 However other respiratory

注意事項(xiàng)

本文(【病毒外文文獻(xiàn)】2010 Human Coronavirus and Acute Respiratory Illness in Older Adults with Chronic Obstructive Pulmonary Disease)為本站會(huì)員(工***)主動(dòng)上傳,裝配圖網(wǎng)僅提供信息存儲(chǔ)空間,僅對(duì)用戶上傳內(nèi)容的表現(xiàn)方式做保護(hù)處理,對(duì)上載內(nèi)容本身不做任何修改或編輯。 若此文所含內(nèi)容侵犯了您的版權(quán)或隱私,請(qǐng)立即通知裝配圖網(wǎng)(點(diǎn)擊聯(lián)系客服),我們立即給予刪除!

溫馨提示:如果因?yàn)榫W(wǎng)速或其他原因下載失敗請(qǐng)重新下載,重復(fù)下載不扣分。




關(guān)于我們 - 網(wǎng)站聲明 - 網(wǎng)站地圖 - 資源地圖 - 友情鏈接 - 網(wǎng)站客服 - 聯(lián)系我們

copyright@ 2023-2025  zhuangpeitu.com 裝配圖網(wǎng)版權(quán)所有   聯(lián)系電話:18123376007

備案號(hào):ICP2024067431號(hào)-1 川公網(wǎng)安備51140202000466號(hào)


本站為文檔C2C交易模式,即用戶上傳的文檔直接被用戶下載,本站只是中間服務(wù)平臺(tái),本站所有文檔下載所得的收益歸上傳人(含作者)所有。裝配圖網(wǎng)僅提供信息存儲(chǔ)空間,僅對(duì)用戶上傳內(nèi)容的表現(xiàn)方式做保護(hù)處理,對(duì)上載內(nèi)容本身不做任何修改或編輯。若文檔所含內(nèi)容侵犯了您的版權(quán)或隱私,請(qǐng)立即通知裝配圖網(wǎng),我們立即給予刪除!